The average weight of newborn babies is approximately 7.25 pounds, height: 19.5 inches long. Obviously, these parameters, which are affected by the human growth hormone (somatotropin/somatropin), change throughout their lives. Here we’ll be familiarizing you with the HGH meaning and peculiarities of the hormone’s influence.
Let’s get a deeper insight into the history of its discovery. The invention of growth hormone (by Evans and Long) dates back to the 20s. In 1944, scientists got the crystalline substance from the animals’ pituitary. Somatotropin, which exists in the human organism, was initially isolated in 1956. It was first administered in 1958. The patient was a child suffering from a dysfunction of this hormone emission. The results of HGH therapy were positive, which served as an impetus for further application of this hormone.
What is HGH? Signs of its Deficiency
What is HGH? Growth hormone (HGH, GH) is a pleiotropic protein, comprising 191 amino acids. The anterior pituitary gland secretes it. Our brains produce varying quantities of this vital agent throughout life. Its secretion rate is the highest during adolescence (the period of the maximal growth).
Endogenous GH has a wide variety of actions including stimulating gametogenesis and steroidogenesis, promoting testicular growth, modulating ovarian function (suggested effect), ensuring longitudinal growth of the body, regulating nonendothelial-dependent actions, etc.
As stated by Spanish scientists Jesus Devesa, Cristina Almenglo, and Pablo Devesa (Medical Center Foltra, Teo, 2016), the activation of multiple proteins involving cellular signaling causes these remarkable effects.
GH deficiency in adults presents itself with:
- Obesity (the abdomen sees the biggest accumulation of weight)
- Atherosclerosis at the early stage
- Increased cholesterol level in the blood
- Poor workability
- Disorders of sexual function
Decelerated physical development in children comes from insufficiency of somatotropin. The disease is rare, but unpleasant, as it makes a person feel uncomfortable among peers. So, adequate responses and effectual therapies should be provided to support the kid.
There are various complicated reasons for low hormone levels. The severity of the disorder also varies from a complete absence of secretion to inadequately poor production. Other problems with pituitary gland’s functioning can accompany the disease, which triggers dramatic growth delays, thyroid dysfunction, delay in sexual maturity, and adrenal insufficiency.
The causes of such disturbances:
- Ailments and diseases a mother faces during pregnancy
- Congenital genetic dysfunctions
- Birth traumas
- Severe head injuries
- Brain tumors
The condition may be the consequence of radiation therapy as a part of cancer treatment. Here, a hormonal deficiency associated with the activity of the brain and signaling for the formation of much-needed GH may develop.
Artificial HGH Meaning: Properties, Brands on the Market
Following a personalized schedule, you can introduce this hormone to the system. The medication affects the glands of internal secretion. Staying influenced, they trigger linear growth of bones, musculature increase, and fat splitting acceleration. Somatropin inhibits collagen ruination in tissues and prevents the development of enzymes—those featuring the destructive impact on amino acids.
Sufficient amounts of HGH induces cells’ (of adrenal glands, liver, gonads, thyroid gland) quantity and size growth. It also stimulates fat breakdown, which causes the boost of fatty acids concentration. This process depresses the influence of insulin on glucose transportation.
Where to get the drug? From an online pharmacy, of course. Usually, these sellers also offer anabolics, such as Andriol and Halodrol, natural steroids (herbal supplements), and Chinese steroids for sale as well.
GH products are marketed under the following brands:
- Geref Diagnostic (sermorelin)
- Egrifta (tesamorelin)
- Eutropin, Saizen (brands in India)
HGH Results (Benefits)
For achieving a maximum positive effect, you must be knowledgeable about the preparation’s properties before its administration. If you do everything correctly, you’ll experience the following HGH benefits:
- Activation of the natural recovery of the body, elimination of devastating factors
- Rejuvenation effect
- Strengthening of bone tissue
- Decreased fat layer thickness (weight loss effect)
- Rising muscle mass
- Ensuring the body’s protection
- Brain activity activation
- Bettered intellectual abilities
- Removing excess lipid molecules
- Excellent sex drive
Properties of HGH Injections
The use of artificial somatotropin is rampant in bodybuilding. Sportspeople resort to it for enhancing muscle definition by lessening the fat layer.
Some physicians assure that the medication, which leads to sugar content increasing, is unrecommended for patients with diabetes. But this standpoint is erroneous, which has been confirmed by recent research in this field. Diabetics simply need to monitor their glucose levels carefully during the application.
The drug possesses an insulin antagonistic feature. Its use provokes an uncharacteristic dissonance between the lack of both secreted by the body and what’s coming from outside hormones.
Thus, it’s necessary to adjust the amount of administered insulin during GH therapy. You must be particularly mindful during the initial two weeks of the treatment. Usually, specialists recommend augmenting the dose of insulin gradually (by one to three units).
Hypertensive individuals should be cautious as the medication affects arterial tension. The solution triggers the decline of sodium chloride (NaCl) consumed. Anyway, to exclude undesirable consequences, be sure to consult your doctor.
Pharmaceuticals containing somatotropin never provide instantaneous effects. The long-lasting transformation happens gradually.
Proper Injection of HGH
Manufacturers of this product propose the following instructions:
Find a suitable place for manipulation. Producers suggest the abdominal area (on average, 8 cm from the navel) as the most optimal. Introduce the needle between the muscles and the skin. The best option is to find a zone that is less painful each time.
Stagger injection sites, so as not to overload one area. The drug’s components, when applied locally, can induce lipodystrophy. The manifestation of fat ruination at the site of administration is observed.
Hold the syringe at the angle of 45° while injecting the liquid. Don’t hurry, do it slowly. To avert the leakage of the substance, stay in such position for approximately five to 10 seconds.
Wash and disinfect your hands with spirit before the procedure to avoid infections.
The ampoule’s neck must be sterilized—rubbed with an alcohol swab, cotton wool, or napkin. Do the same with the skin of the injection site.
Before the infection, make sure the syringe is free from air bubbles.
HGH Dosage and Side Effects
The recommended duration of the cycle is up to seven months (beginner steroid cycles may last for less time). You will definitely get the superior efficiency if the course begins with the lowest dose, slowly adding in small increments. Physicians advise lessening the medication’s amount at the end of the course.
The optimal HGH dosage at the first stage is 4 units (IU for one injection). After 30 days, you’re free to add 0.5 units, and after 7 days you may resort to 5 units (two 2.5-unit injections). If you notice any adverse events (joint pain, bloating) reduce the dose.
Allergic reactions may occur in the injection (see steroid injection side effects). Never skip doses, except in cases of severe negative effects. HGH features anabolic nature, which may provoke serious negative effects, in contradiction to steroid nasal spray side effects, for example. The medicament may be dangerous for females (women on steroids photos are sometimes terribly frightening).
HGH is activated within three hours of appearing in the organism. In individuals younger than 45, the substance’s emission occurs during sleep (nighttime slumber or even daytime napping). This aspect determines the most suitable time for injection-after waking up (usually morning). It promotes artificial prolongation of this natural process. If you’re injecting 5 units of somatropin (twice daily), do the second one at noon, when the cortisol’s concentration is the highest.
Keep in mind these recommendations:
- Store the ready-made injection solution in a cold place (in the refrigerator with a temperature of 2 to 8 degrees Celsius (around 45 degrees Fahrenheit).
- Hide the ampoule from direct sunlight exposure, heating and freezing should be avoided.
- The expiry date for a dry powder is up to 2 years.
- Make the infusion on an empty stomach, don’t eat for 40 minutes after the procedure.
- Don’t exceed the frequency of the manipulations (make breaks at least 4 hours between).
To increase the effectiveness of this remedy, you should mindfully and responsibly consider your diet. Consumption of protein in an amount of two to three grams per 1 kg of the body weight is essential. Get rid of foods containing easily digested carbohydrates. Substitute them with “good” carbs and healthy fats.
How to Improve HGH Effects
HGH isn’t enough for achieving hyperactive musculature growth alone. For attaining serious gains, its combination with insulin is a perfect choice. You need to inject this peptide hormone, aimed at significant relief of the load experienced by the pancreas.
- Insulin glulisine (Apidra)
- Insulin aspart (Novolog)
- Novolin R (Novo Nordisk)
- Humulin R (Eli Lilly)
- Insulin lispro (Humalog)
- Insulin glargine (Basaglar, Lantus, Toujeo)
- Insulin degludec (Tresiba)
- Insulin detemir (Levemir)
Indian brands include Human Zinulin, Humanext-N, Huminsulin, Humstard, Insucare-N, Insugen, Insugen, Insuman-Comb, Lentisulin, Lupisulin, Mixtard, Rapimix, Rapisulin, and Wosulin.
The most appropriate dosage of insulin is from 6 to 8 units (IU). The injection must be performed before a meal, which is a suitable time for muscle enlargement and acceleration of metabolism. A concrete dose of these hormones should be selected individually by a licensed specialist.