The average weight for a newborn baby is approximately 7.25 pounds, height – 19.5 inches. Obviously, these parameters, affected by human growth hormone (somatotropin/somatropin), change throughout the life. Before we familiarize you with HGH meaning and peculiarities of the hormone’s influence.
Let‘s get a deeper insight into the history of its discovery.The invention of growth hormone (by Evans and Long) dates back to the 1920s. In 1944 scientists got the crystalline substance from the animals’ pituitary. Somatotropin, which exists in human organism, was isolated in 1956. It was first administered in 1958. The patient was a child with dysfunction of this hormone emission. The results of HGH therapy were positive, which served as an impetus for further application of this hormone.
What is HGH? Signs of its Deficiency
What is HGH? Growth hormone (HGH, GH) is a pleiotropic protein, comprising 191 amino acids. The anterior pituitary gland secretes it. Different quantity of this vital agent is produced by organism during the entire life. Its secretion rate is the highest at adolescence (the period of the top growth jump).
Endogenous GH has a wide variety of actions including stimulating gametogenesis and steroidogenesis, promoting testes’ growth, modulating ovarian function (suggested effect), ensuring longitudinal growth of the body, activating the NO system, regulating nonendothelial-dependent actions, etc. As stated by Spanish scientists Jesus Devesa, Cristina Almenglo, and Pablo Devesa (Medical Center Foltra, Teo, 2016), this is due to activating multiple proteins involved in cell signaling.
GH deficiency in adults is manifested by:
- Obesity (abdomen area is the place of the biggest accumulation).
- Atherosclerosis at the early stage.
- Increased cholesterol level in the blood.
- Poor workability.
- Disorders of sexual function.
Retard physical development in children is caused by insufficient quantity of somatotropin. The disease is not frequent, but unpleasant, as it makes a person feel uncomfortable among peers. That is why, an adequate respond and effectual therapy should be provided.
There are various complicated reasons of low hormone level. The severity of the disorder also varies from complete absence of secretion to inadequately poor production. The disease can be accompanied by other problems with pituitary gland’s functioning, which triggers strong growth retardment, thyroid dysfunction, delay in sexual maturity, adrenal insufficiency.
The possible causes of such disturbances:
- ailments, diseases, which a mother to-be faces during pregnancy;
- congenital genetic disfunctions;
- birth trauma, severe head injuries, brain tumor.
The condition may be the consequence of radiation therapy as a part of cancer treatment. In this case, hormonal deficiency, associated with the activity of the brain and signals for the formation of much-needed GH, may develop.
Artificial HGH Meaning: Properties, Brands on the Market
Following a special schedule, you can introduce this hormone into the organism. The medication affects the glands of internal secretion. Staying influenced, they trigger linear growth of bones, musculature increase, fat splitting acceleration. Somatropin inhibits the collagen ruination in tissues, prevents the development of enzymes, featuring the destructive impact on amino acids.
Sufficient amount of HGH induces cells’ (of adrenal glands, liver, gonads, thyroid gland) quantity and size growth. It also stimulates fat breakdown, which causes the boost of fatty acids concentration. This process depresses the influence of insulin on the glucose transportation.
Where to get the drug? You can do it in many online pharmacy. Usually, these stores also offer anabolics, such as Andriol and Halodrol, natural steroids (herbal supplements) and Chinese steroids for sale.
GH products are marketed under the following brands:
- Geref Diagnostic (sermorelin);
- Egrifta (tesamorelin);
- Eutropin, Saizen (brands in India).
HGH Results (Benefits)
For achieving a maximum positive effect, you must be knowledgeable about the preparation’s properties before its administration. If you do everything right, you’ll experience the following HGH benefits:
- activation of the natural recovery of the body, elimination of devastating factors;
- rejuvenation effect;
- strengthening of bone tissue;
- decrease in the fat layer thickness (weight loss effect);
- muscle mass rise;
- ensuring the body’s protection;
- brain activity activation;
- bettered intellectual abilities;
- removing excess lipid molecules;
- excellent sex drive.
Properties of HGH Injections
Artificial somatotropin is widespread in bodybuilding. Sportspeople resort to it for enhancing muscle definition by reducing the fat layer.
Some physicians assure that the medication, which leads to sugar content increasing, is prohibited for patients with diabetes. But this standpoint is erroneous, which is confirmed by recent research in the field of medicine. People who suffer from such disease, need to monitor the glucose level carefully during the application. The drug possesses an insulin antagonistic feature. Its use provokes an uncharacteristic dissonance because of the lack of both secreted by the body and coming from outside hormones.
That is why, it’s necessary to adjust the amount of administered insulin during GH therapy. You must be especially mindful during the first 2 weeks of the treatment. Usually, specialists recommend to augment the dose of insulin gradually (by 1-3 units).
People with hypertension should be cautious, since the medication affects the arterial tension. The solution triggers the decline of sodium chloride (sodium chloride) consumed. Anyway, to exclude undesirable consequences, be sure to consult your doctor.
Pharmaceuticals containing somatotropin never provide instantaneous effect. The long-lasting body transformation happens gradually.
Proper Injection of HGH
Manufacturers of this product propose the following instruction:
- Find a suitable place to make a manipulation. Producers indicate the abdominal area (on average, 8 cm from the navel) as the most optimal one. Introduce the needle between the muscles and the skin. The best option is to find a zone that is less painful each time.
- Each next injection should be given in another area of the skin. The drug’s components, when applied locally, can induce lipodystrophy. The manifestation of fat ruination at the site of administration is observed.
- Keep the syringe at the angle of 45°, while injecting the liquid, don’t hurry, do it slowly. To avert the leakage of the substance, stay in such position approximately from 5 to 10 seconds.
- Wash and disinfect your hands with spirit before the procedure to avoid infections.
- The ampoule’s neck must be rubbed with an alcohol swab, cotton wool or napkin. Do the same with the skin of the injection site.
- Before the infection, make sure the syringe is free from air bubbles.
HGH Dosage and Side Effects
The recommended duration of the cycle is up to 7 months (beginner steroid cycle may last less). You will definitely get the superior efficiency if the course begins with the low dose, increased step-by-step. Physicians advise lessening the medication’s amount at the end of the course.
The optimal HGH dosage at the first stage is 4 units (IU for one injection). After a month you are free to add 0.5 units and after 7 days you may resort to 5 units (two 2.5-unit injections). If you notice any adverse events (joint pain, bloating) the reduction of the preparation’s dose is required. Also, it can trigger allergic reactions in the site of making a shot (like steroid injection side effects). Never miss the drug administration except for cases of severe negative effects. HGH features anabolic nature, which may provoke serious negative effects, in contradiction to steroid nasal spray side effects, for example. The medicament may be dangerous for females (women on steroids photos are sometimes terrible).
HGH is activated in 3 hours after appearing in the organism. In individuals younger than 45, the substance’s emission occurs while a person is sleeping (in a nighttime). (This aspect determines the most suitable time for injection-after waking up (usually in the morning). It promotes artificial prolongation of this natural process. If you are prescribed 5 units of somatropin (two injections a day), do the second one at noon, when the cortisol’s concentration is the highest.
Keep in mind these recommendations:
- Store the ready-made injection solution in a cold place (in the refrigerator with a temperature of + 2 … + 8 °C).
- Hide the ampoule from a direct sunlight exposure, avoid its heating and freezing;
- The expiry date for a dry powder is up to 2 years.
- Make infusion on an empty stomach, don’t eat for 40 minutes after the procedure.
- Don’t exceed the frequency of the manipulations (make brakes at least for 4 hours between them).
To increase the effectiveness of this remedy, you should mindfully and responsibly consider your diet. Consumption of protein in an amount of 2-3 grams per 1 kg of the body weight is essential. Get rid of foods, containing easily digested carbohydrates. Substitute them with “good” carbs and fats.
How to Improve HGH Effects
The HGH isn’t enough for getting hyperactive growth of musculature. For attaining hoped-for gains its combination with insulin is a perfect choice. You need to additionally inject this peptide hormone, aimed at significant relief of the load experienced by the pancreas. Its brands include:
- Insulin glulisine (Apidra);
- Insulin aspart (Novolog);
- Novolin R, Humulin R;
- Insulin lispro (Humalog);
- Insulin glargine (Basaglar, Lantus, Toujeo);
- Insulin degludec (Tresiba);
- Insulin detemir (Levemir);
- Human Zinulin, Humanext-N, Huminsulin, Humstard, Insucare-N, Insugen, Insugen, Insuman-Comb, Lentisulin, Lupisulin, Mixtard, Rapimix, Rapisulin, Wosulin (Indian brands).
The most appropriate dosage of insulin is from 6 to 8 units (IU). The injection must be performed before meal, which is a suitable time for muscle enlargement and acceleration of metabolism. A concrete dose of these hormones should be selected individually by the licensed specialist.