Home Hormones Progesterone in Oil Injections (Shots) during Pregnancy: Side Effects.

Progesterone in Oil Injections (Shots) during Pregnancy: Side Effects.

Posted by admin in Hormones Category. Reviewed and Updated: 31 January, 2018

Progesterone in oil injection is a medication that is prescribed to treat progesterone deficiency in women. During pregnancy, such injections can be prescribed in case of threat of miscarriage.

Progesterone in oil injection – definition, indications, contraindications

Progesterone in oil injection is a drug of synthetic origin, which is used to eliminate various functional disorders of the reproductive system. Also, injections of progesterone can be prescribed by a specialist for the treatment of certain forms of infertility that occur in the beautiful half of the population and to restore a normal menstrual cycle.

To determine low progesterone in women, a female patient must undergo certain tests on the twenty-third day from the beginning of the critical days. Only a laboratory blood test can give an accurate result on whether hormonal therapy is necessary.

Progesterone in ampoules is available in the form of one milliliter of 1% or 2.5% solution. After the injection, the drug is very quickly absorbed into the bloodstream and its effect occurs an hour after the injection.

Basic indications for use of this drug form are as follows:

  • Natural lowering of the natural level of the hormone in the female body;
  • Emerging bleeding, having nothing to do with menses;
  • The drug can be prescribed to adjust the duration of the menstrual cycle, while a health care specialist must first make sure that the woman is not pregnant;
  • Abundant menstrual cycle;
  • Low progesterone levels in the blood of a prospective mother;
  • In case of a threat of miscarriage;
  • If a woman has already had several unsuccessful pregnancy attempts, which has resulted in spontaneous rejection of the fetus;
  • Corpus luteum deficiency in the female body.


During pregnancy, the drug should be used only to prevent and treat a miscarriage threat. After the 36th week of pregnancy, the use of the drug is contraindicated. Women who are planning pregnancy in the near future should avoid the medication. The risk of congenital anomalies, including sexual anomalies in children of both sexes, associated with the action of exogenous progesterone during pregnancy, is not fully established. Progesterone penetrates into breast milk, so the drug should not be used during breastfeeding.

To prevent and treat the threat of miscarriage caused by the yellow body deficiency, progesterone is administered in the dosage of 10-25 mg daily or every other day until the risk of miscarriage is completely eliminated. In case of frequent miscarriages, the drug can be administered up to the 4th month of pregnancy.

According to the instructions, the drug should be used with extreme caution by patients who suffer from asthma, kidney failure and abdominal/tubal pregnancy. Progesterone should also be used with caution by patients with mental disorders, it must be discontinued with the first signs of depression.

Progesterone injection site – where to inject?

Most often, injections of the drug are administered intramuscularly or subcutaneously. The most common method is intramuscular injection, since this is the less painful method while the subcutaneous injection of the medication is often accompanied by indurations and even bruises.

How to choose a progesterone injection site? Intramuscular injection should be made in the muscle of the buttock. It is important not to get into the big nerves that are located somewhere in the middle of the buttock. To do this, select injection site by the following way:

  • Imagine that the buttock is divided into 4 equal squares.
  • Now look closer at the upper, square: imagine that it consists of 2 triangles by a line, which runs downward from the inside to outer corner.
  • The proper area for the shot is inside the upper outer triangle.

Progesterone injections side effects

A long course of treatment can cause the following progesterone injections side effects in the body:

  • Increased blood pressure and swelling;
  • Nausea, vomiting and impaired liver function;
  • Depressive condition and systematic headaches;
  • Fast gain of body weight and a significant decrease in sexual desire;
  • Coarsening and painfulness of the mammary glands;
  • Increase in blood clotting;
  • Increased drowsiness;
  • The appearance of allergic reactions to the drug;
  • The places where injections were made become painful.

With regard to reviews of the drug, they are mostly positive and many women who have had problems with normal childbearing, note the effectiveness of the application. However, you can encounter negative reviews, which are associated mainly with the occurrence of side effects after the use of the drug.

Some women do not notice any changes that could affect their health. Anyway, it is not advisable, relying on reviews, to try to engage in self-medication. You need to consult a doctor who will prescribe the correct medication in the proper dosage.

Others forms of the drug

Today, progesterone is available not only in the form of injections, but also in the form of tablets, capsules and gel. In medical practice, progesterone in tablets is prescribed for oral administration, in capsules – for intravaginal administration, and the gel is accordingly intended for external use only.

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