Home Hormones How to Use Progesterone Suppositories: Instructions and Side Effects.

How to Use Progesterone Suppositories: Instructions and Side Effects.

Posted by admin in Hormones Category. Reviewed and Updated: 27 March, 2019

Progesterone deficiency is a fairly common reason that couples encounter when planning a child, and many women experience during pregnancy. For the treatment of progesterone insufficiency, you can use vaginal forms of progesterone meds (Endometrin, Progesterone VGS, etc.). These forms are called suppositories. How to use progesterone suppositories? What side effects can they cause? In this article, you will find the answers to these and other questions.

What Are Progesterone Suppositories?

Medicos prescribe suppositories containing progesterone for women, planning gravidness, to prepare the uterus’ inner wall for fixing an egg, which is fertilized, on it. For pregnant patients, its administering is necessary for the purposes of promoting endometrium’s thickening. The pharmacon also contributes to proliferation of the blood vessels’ system, required for maintaining the embryo’s viability. The main target of progesterone suppositories is the preparation of a female reproductive system for childbearing and the averting of miscarriage. Don’t use the drug if you are pregnant (unless the medication is part of the treatment for improving fertility, when it can be used in early pregnancy, as prescribed by the doctor).

Scientific data regarding the suppositories is as follows:

  • Fakhrolmolouk Yassaee, Reza Shekarriz-Foumani et al. (Taleghani Hospital, Shahid Beheshti University, 2014): they reduce the rate of abortion in case of threatened abortion, but the difference isn’t statistically significant;
  • Eduardo B. da Fonseca, Roberto E. Bittar, Mario H.B. Carvalho et al. (Obstetrics Clinic, University of São Paulo, 2003): progesterone supplementation decreases the risk of recurrent preterm birth at all gestational ages studied and may maintain uterine quiescence in the latter half of pregnancy;
  • Jerome H Check (UMDNJ, 2009): comparisons to the vaginal gel and intramuscular shots have shown similar efficiency especially in trials following controlled ovarian hyperstimulation, oocyte egg retrieval and embryo transfer;
  • Meena Khandelwal (Cooper University Hospital, Camden, 2012): intravaginal progesterone reduces preterm birth risk in females with a short cervix in the midtrimester of pregnancy; the drug’s benefits outweigh its risks.

Progesterone Suppository Instructions — What Should You Consider Before Use?

The instructions forbid using this medication if you suffer or have suffered from an allergy associated with synthetic progesterone. Also, before the administration of the medicine, inform the healthcare professional about the following facts:

  • stroke, circulatory problems;
  • breast cancer, which you have currently or have experienced early;
  • bleeding in the vagina;
  • severe hepatic diseases;
  • any kind of food allergy (this is because vegetable oils can be the component of the remedy which can trigger an allergic reaction);
  • recent ectopic pregnancy or an incomplete abortion.

If the above conditions (diseases) are observed at the present moment, the drug is contraindicated.

In addition, tell your medical expert if you face high blood pressure, kidney disease, asthma and lugubriosity (depression). This will allow the doctor to determine whether the treatment is safe for you.

How to Use Progesterone Suppositories Properly?


Here is how to use progesterone suppositories. First of all, you need to scrupulously study the instructions for being aware of all its characteristics. If you don’t understand some information, ask your doctor or pharmacist about it. Using suppositories in both smaller and larger quantities than indicated by the specification isn’t permitted.

You shouldn’t take the medication orally. It’s intended exclusively for vaginal use.

How to insert a suppository? It should be inserted directly into the vagina, using the applicator, which is attached to the product. This applicator serves only for single use, so after intravaginal administration, it must be discarded.

Vaginal suppositories are supplied in special containers. The pharmacist can show you how to get it from the container properly, adhering to the rules of hygiene. Don’t keep the suppository in your hands for too long as it can begin to melt. If the medicine causes wooziness and severe drowsiness, use it before going to bed. Most likely, in the morning, there will be no trace from these side effects. The medication should be stored in the icebox. Follow these rules for the proper application.

What to do if you missed the dosage of the medication? You can apply the missed dose if there is still a lot of time before the next administration of the suppository in accordance with the schedule, created by the doctor. If you are approaching the time for a new dosage, skip the missed one. Don’t use an increased amount to compensate for the deficiency. If you missed two or more administrations, call your healthcare provider to find out how to solve the problem.

What to with an overdose? Usually, an overdosage isn’t associated with serious adverse events. Call an ambulance if you see that someone swallowed a suppository by accident.

How is the drug withdrawn? The drug is withdrawn gradually, according to the expert’s recommendations. For this, the dosage is gradually reduced weekly. But if the symptoms of a threatening miscarriage appear again in the form of bleeding, pulling pain in the lower abdomen, the treatment must be resumed. Otherwise, a miscarriage can happen. Abrupt drug canceling isn’t allowable because it can provoke an abortion.

Duphaston is an analogue of the medication. It presents in the pills for oral administration. Unlike suppositories, it usually doesn’t have a sedative effect, so some doctors prefer to prescribe it. Suppositories or tablets are currently preferable to injections. Infusions of oil solutions are very painful and require special skills while a woman can apply “candles” herself. These medicines aren’t available over the counter, they can only be purchased if you have a prescription issued by a competent physician.

Progesterone Suppositories: Contraindications and Side Effects

The remedy is contraindicated in case of:

  • malignant tumors of the breast and genital organs;
  • unidentified bleeding from the genital tract;
  • high sensitivity to the drug’s constituents (soy and peanut butter).

The oral intake is prohibited if a woman has: severe disorders of the liver; predisposition to thrombosis or thrombophlebitis (increased blood clots, accompanied by inflammation of the veins in places where they are blocked by thrombi).

If a female person is in the lactation period, the interruption of the breastfeeding is advised.

Artificial progesterone should be taken with caution in case of:

  • dysfunctions of the cardiovascular system;
  • unabate (chronic) renal failure;
  • diabetes;
  • epileptic disorders – focal seizures (aura), generalized seizures (tonic-clonic, tonic, clonic, myoclonic, absence, atonic);
  • bronchial asthma;
  • increased blood pressure;
  • headache;
  • anxiety, depression;
  • hyperlipoproteinemia (excess lipoproteins and / or lipids in the blood).

Negative consequences may occur in several hours after taking. They are drowsiness, which turns into dizziness. Allergic reactions are possible as well. Other progesterone suppositories adverse events include pain during urination, mood jumps, reluctance to do anything and suchlike, vision problems, impaired liver function and some other unwanted outcomes.

Many medications may interact negatively with progesterone suppositories. If you are taking any medicines (as well as OTC supplements and even herbs), acquaint your doctor with it.

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