Estradiol is one of the sex hormones. The follicular system of the ovaries and placenta are responsible for its secretion in females. In males, it’s emitted by testicles. The adrenal cortex and adipose tissue involving aromataze enzyme produce this hormone in the representatives of both sexes. The traditional belief, concerning the division of hormones into two groups, namely exclusively “male” (androgens) and “female” (estrogens, and progesterone) is incorrect. All sex hormones have a steroidal nature. They are also characterized by the following features: 7-dihydrocholesterol is their biomechanical precursor; progesterone-is their hormonal “progenitor”; the synthesis occurs under almost a uniform pattern; found in both men and women and are vital for providing the necessary quality of life.
People can face low testosterone or its increased level. Experiences with these irregularities are not limited to just testosterone. The same can happen with estradiol. There are many reasons why this would occur. While there are natural changes between individuals and across a lifetime, there are some cases with more sinister causes than others.
Normal Estradiol Levels
In not pregnant women, the hormone’s concentration is determined by luteinizing and follicle-stimulating hormones. It depends on the extent of the follicle’s maturing. Consequently, the gradual enhancing of the estradiol’s amount takes place before ovulation. In the middle of the menstrual cycle, it reaches the highest position and slows down in the luteal phase. The rate is minimal at the end of the menstruation. Daily fluctuations of its level happen because of the rhythm of the luteinizing hormone’s emission. From 3 pm to 6 pm the rate is maximal, from midnight and 2 am, it is the lowest.
According to Mayo Medical Laboratories information, in menstruating females, the hormone level ranges from 15 to 350 picograms per milliliter (pg/mL). In postmenopausal ones, normal rates are lower than 10 pg/mL.
Normal values of estradiol in children are as follows:
|0-15 days||less than 32 pg/mL||up to 36 pg/mL|
|0.5 months – 10 years||up to 21 pg/mL||up to 36 pg/mL|
|10–18 yo||7-18 pg/mL||lower than 350 pg/mL|
Estradiol Insufficiency (Low Levels) in Men and Women
In females, the lack of estradiol is observed during menopause or after it. It’s considered a completely natural process and is not associated with any unpleasant conditions.
The opposite situation is with women of reproductive age. If you are not in at menopausal age, this can be the first sign of a problem. In order to resume a healthy reproductive life, you will need to address this. This is not just a matter of inconvenience, in some cases, poor estradiol level may be the sign of numerous diseases:
- Hypogonadism. This is malfunctions of the genital organs and mammary glands in women, which triggers their atrophy. There are many causes, which provokes the disorder, namely genetic pathology, inflammation, ovarian hypoplasia, radiation, pituitary or hypothalamic tumor, etc.
- Pituitary dwarfism, or deficit of human growth hormone – is manifested by a delay in linear growth (dwarfism) and physical development, which was triggered by poor pituitary work and inadequate hormone emission.
- Luteal phase defect – is occurred when the yellow body is “reluctant” to supply the organism with a sufficient quantity of progesterone.
- Viral syndrome. The secondary sexual characteristics appear because of surplus amounts of androgens and genital organs’ depletion. A tumor of the ovaries, pituitary gland, adrenal glands, hypothalamus often induces it;
- Turner syndrome. This disease has a genetic nature and is caused by a structural disorder of the X-chromosome. It’s accompanied by pathological in the development of internal organs and low growth;
- Inflammation of internal genital organs, etc.
The abnormal level of estradiol is manifested by the following symptoms:
- menstruation cycle disorder;
- premenstrual syndrome;
- dryness and burning in the vagina;
- low sexual drive;
- blood pressure fluctuation;
- rapid change of body weight.
Male persons experiencing estradiol deficiency have problems with blood vessels, bones, and potency.
You might be interested in how to boost testosterone levels naturally.
High Estradiol Rate in Women
The hormone level increases against the background of the following health conditions: persistence of the follicle (folliculus ovaricus); follicular cyst of ovaries; endometriosis, liver cirrhosis, obesity. Acne, hair loss, poor skin condition, menstruation disorder are the typical signs. In addition, both male and female observe obesity, swelling, gastrointestinal system disorder, mood swing, sweating, poor sleep, and anxiety. These signs are shared symptoms from numerous other diseases. In order to determine the absolute cause of your problems, a professional physical examination and lab results are needed.
High Estradiol Levels in Men
This health condition can be caused by the following factors common for both sexes:
- cirrhosis of liver
- poor functioning of the thyroid gland
- use of certain drugs, namely testosterone enanthate and oxandrolone, etc.
Males may experience low libido, gyno, heart and vessels diseases, benign or malign prostate tumor.
Doctors recommend such patients to follow a low-carbohydrate, protein-enriched and fish-based diet.
It is important: if you suspect you have inadequate estradiol level, don’t self-medicate, as you can only do harm to your health. Consult a doctor to get appropriate treatment. They have received years of medical training to understand human anatomy. Relying off of online resources can lead to some problems as these articles are meant to help and are not an expert diagnostic tool, nor should they be treated as a concrete diagnosis.